PI Publications
- 2024Immunomodulation by juglone alleviates acute graft-versus-host disease without compromising the graft-versus-leukaemia activity in mice. British Journal of Pharmacology, Online ahead of print
Gohil, D., Gandhi, K. A., Gupta, S. K., Gera, P., Yadav, S., Patwardhan, R., Checker, R., Sharma, D., Khattry, N., Sandur, S., & Gota, V. (2024)
Predictive performance of population pharmacokinetic models of imatinib in chronic myeloid leukemia patients. Cancer Chemotherapy and Pharmacology, Online ahead of printBatcha, J. S. D., Gota, V., Matcha, S., Raju, A. P., Rao, M., Udupa, K. S., & Mallayasamy, S. (2024)
Preclinical evaluation of engineered L-asparaginase variants to improve the treatment of Acute Lymphoblastic Leukemia. Translational Oncology, 43, 101909Sengupta, S., Biswas, M., Gandhi, K. A., Gupta, S. K., Gera, P. B., Gota, V., & Sonawane, A. (2024)
Withania Somnifera Extract Mitigates Experimental Acute Graft versus Host Disease Without Abrogating Graft Versus Leukemia Effect. Cell Transplantation, 33, 9636897241226573Gupta, S. K., Gohil, D., Momin, M. B., Yadav, S., Chichra, A., Punatar, S., Gokarn, A., Mirgh, S., Jindal, N., Nayak, L., Hingorani, L., Khattry, N., & Gota, V. (2024)
Bioequivalence study followed by model-informed dose optimization of a powder for oral suspension of 6-mercaptopurine. Pediatric Blood & Cancer, 71(3), e30813Arun, B., Joshi, M., Kakkar, A. K., Madki, S., Ivaturi, V., Chinnaswamy, G., Banavali, S., & Gota, V. (2024)
Performance of potentially inappropriate medications assessment tools in older Indian patients with cancer. Cancer Medicine, 13(1), e6797Kumar, S., Castelino, R., Rao, A., Gattani, S., Kumar, A., Pillai, A., Sehgal, A., Rane, P., Ramaswamy, A., Dhekale, R., Krishnamurthy, J., Banavali, S., Badwe, R., Prabhash, K., Noronha, V., & Gota, V. (2024)
Mitocurcumin utilizes oxidative stress to upregulate JNK/p38 signaling and overcomes Cytarabine resistance in acute myeloid leukemia. Cell Signal, 114, 111004Gaur, T., Ali, A., Sharma, D., Gupta, S. K., Gota, V., Bagal, B., Platzbeckar, U., Mishra, R., Dutt, A., Khattry, N., Mills, K., Hasan, M. I., Sandur, S., & Hasan, S. K. (2024)
Mitochondrial-targeted curcumin inhibits T-cell activation via Nrf2 and inhibits graft-versus-host-disease in a mouse model. Phytotherapy Research, 38(3), 1555–1573Patwardhan, R. S., Gohil, D., Singh, B., Kumar, B. K., Purohit, V., Thoh, M., Checker, R., Gardi, N., Gota, V., Kutala, V. K., Patwardhan, S., Sharma, D., & Sandur, S. K. (2024)
- 2023Phase II trial of a novel chemotherapy regimen CVEP (cyclophosphamide, vinblastine, etoposide and prednisolone) for acquired immunodeficiency syndrome (AIDS)-associated lymphomas. Br J Haematol, 200(4), 429-439. PMID: 36323643
Sengar, M., Jain, H., Shet, T., Sridhar, E., Gota, V., Rangarajan, V., Laskar, S. S., Alahari, A., Thorat, J., Agarwal, A., Sharma, N., Gupta, H., Kannan, S., Kumar, S., Nayak, L., Menon, H., Gujral, S., & Bagal, B. (2023)
Withaferin-A alleviates acute graft versus host disease without compromising graft versus leukemia effect. International Immunopharmacology, 121, 110437Kumar Gupta, S., Gohil, D., Dutta, D., Panigrahi, G. C., Gupta, P., Dalvi, K., Khanka, T., Yadav, S., Kumar Kaushal, R., Chichra, A., Punatar, S., Gokarn, A., Mirgh, S., Jindal, N., Nayak, L., Tembhare, P. R., Hasan, S. K., Kumar Sandur, S., Hingorani, L., Khattry, N., & Gota, V. (2023)
Effect of Moderate Malnutrition on the Pharmacokinetics of Etoposide and Vincristine in Freshly Weaned Rats. European Journal of Drug Metabolism and Pharmacokinetics, 48(6), 657–663Garg, M., Gandhi, K., Jadhav, S. M., Gurjar, M., & Gota, V. (2023)
- 2022Phase I Study Evaluating Dose De-escalation of Sorafenib with Metformin and Atorvastatin in Hepatocellular Carcinoma (SMASH). Oncologist, 27(3), 165-e222. PMID: 35274724.
Ostwal, V., Ramaswamy, A., Gota, V., Bhargava, P. G., Srinivas, S., Shriyan, B., Jadhav, S., Goel, M., Patkar, S., Mandavkar, S., Naughane, D., Daddi, A., Nashikkar, C., Shetty, N., Ankathi, S. K., & Banavali, S. D. (2022)
Role of Curcumin in Reducing Toxicities Associated With Mucosal Injury Following Melphalan-Based Conditioning in Autologous Transplant Setting. Cell Transplant, 31, 9636897221086969. PMID: 35435039Punatar, S., Katti, K., Rajamanickam, D., Patil, P., Dhakan, C., Bagal, B., Gokarn, A., Bonda, A., Nayak, L., Gurjar, M., Kannan, S., Chiplunkar, S., Gota, V., & Khattry, N. (2022)
Feasibility of therapeutic drug monitoring of sunitinib and its implications on response and toxicity in patients with metastatic renal cell cancer. Cancer Chemother Pharmacol, 89(6), 751-759. PMID: 35441269Gandhi, K. A., Joshi, A., Mehta, P., Gurjar, M., Rane, P., Sharma, J., Patil, A., Nookala, M., Noronha, V., Prabhash, K., & Gota, V. (2022)
Role of ADME gene polymorphisms on imatinib disposition: results from a population pharmacokinetic study in chronic myeloid leukaemia. Eur J Clin Pharmacol, 78(8), 1321-1330. PMID: 35652931Shriyan, B., Mehta, P., Patil, A., Jadhav, S., Kumar, S., Puri, A. S., Govalkar, R., Krishnamurthy, M. N., Punatar, S., Gokarn, A., Khattry, N., & Gota, V. (2022)
Acute and sub-acute oral toxicity assessment of 5-hydroxy-1,4-naphthoquinone in mice. Drug Chem Toxicol, 1-14. PMID: 35899689Gohil, D., Panigrahi, G. C., Gupta, S. K., Gandhi, K. A., Gera, P., Chavan, P., Sharma, D., Sandur, S., & Gota, V. (2022)
A prospective, open-label, randomised, parallel design study of 4 generic formulations of intramuscular L-asparaginase in childhood precursor B-cell acute lymphoblastic leukaemia (ALL). Cancer Chemother Pharmacol, 90(6), 445-453. PMID: 36251032Johnson, S., Dhamne, C., Sankaran, H., Gandhi, K. A., Rane, P., Moulik, N. R., Jadhav, S. M., Gurjar, M., Narula, G., Banavali, S., & Gota, V. (2022)
Safety, toxicity and pharmacokinetic assessment of oral Withaferin-A in mice. Toxicology Reports, 9, 1204–1212. https://doi.org/10.1016/j.toxrep.2022.05.012Gupta, S. K., Jadhav, S., Gohil, D., Panigrahi, G. C., Kaushal, R. K., Gandhi, K., Patil, A., Chavan, P., & Gota, V. (2022)
- 2021Simultaneous analysis of urinary total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, N'-nitrosonornicotine, and cotinine by liquid chromatography-tandem mass-spectrometry. Scientific reports, 11(1), 20007. https://doi.org/10.1038/s41598-021-99259-z
Nikam, S. S., Gurjar, M., Singhavi, H., Patil, A., Singh, A., Villalta, P., Chaturvedi, P., Khariwala, S. S., Gota, V., & Stepanov, I.
Salivary Raman Spectroscopy: Standardization of Sampling Protocols and Stratification of Healthy and Oral Cancer Subjects. Applied spectroscopy, 75(5), 581–588. https://doi.org/10.1177/0003702820973260Hole, A., Tyagi, G., Deshmukh, A., Deshpande, R., Gota, V., Chaturvedi, P., & Krishna, C. M.
Pharmacokinetics of solid lipid Boswellia serrata particles in healthy subjects. Drug metabolism and personalized therapy, 10.1515/dmdi-2020-0176. Advance online publication. https://doi.org/10.1515/dmdi-2020-0176Kulkarni, P. D., Damle, N. D., Hingorani, L., Bhaskar, V. H., Ghante, M. R., Patil, A., Gurjar, M., & Gota, V.
Effect of body mass index on pharmacokinetics of paclitaxel in patients with early breast cancer. Cancer medicine, 10(9), 3068–3076. https://doi.org/10.1002/cam4.3865Gota, V., Nookala, M., Bonda, A., Karanam, A., Shriyan, B., Kembhavi, Y., Gurjar, M., Patil, A., Singh, A., Goyal, N., & Gupta, S.
Lipocalin 2 expression promotes tumor progression and therapy resistance by inhibiting ferroptosis in colorectal cancer. International journal of cancer, 149(7), 1495–1511. https://doi.org/10.1002/ijc.33711Chaudhary, N., Choudhary, B. S., Shah, S. G., Khapare, N., Dwivedi, N., Gaikwad, A., Joshi, N., Raichanna, J., Basu, S., Gurjar, M., P K, S., Saklani, A., Gera, P., Ramadwar, M., Patil, P., Thorat, R., Gota, V., Dhar, S. K., Gupta, S., Das, M., … Dalal, S. N.
Chloroform extract and acetyl-11-keto-beta-boswellic acid from Boswellia dalzielii stem bark induce apoptosis and cell cycle blockage in AW8507 cells. Journal of the Egyptian National Cancer Institute, 33(1), 20. https://doi.org/10.1186/s43046-021-00075-3Otitoju, A. P., Longdet, I. Y., Alemika, T. E., & Gota, V. P.
ADME gene polymorphisms do not influence the pharmacokinetics of docetaxel: Results from a population pharmacokinetic study in Indian cancer patients. Cancer medicine, 10(14), 4948–4956. https://doi.org/10.1002/cam4.4026Patil, A., Shriyan, B., Mehta, P., Patil, M., Gurjar, M., Nookala, M., Patil, V., Joshi, A., Noronha, V., Prabhash, K., & Gota, V.
Validation of a novel causality assessment scale for adverse events in non-small cell lung carcinoma patients treated with platinum and pemetrexed doublet chemotherapy. Therapeutic advances in drug safety, 12, 2042098621991280. https://doi.org/10.1177/2042098621991280Sharma, J. B., Krishnamurthy, M. N., Awase, A., Joshi, A., Patil, V., Noronha, V., Prabhash, K., & Gota, V.
3,3'-Diselenodipropionic acid (DSePA) induces reductive stress in A549 cells triggering p53-independent apoptosis: A novel mechanism for diselenides. Free Radic Biol Med, 175, 1-17. PMID: 34425189Gandhi, V. V., Gandhi, K. A., Kumbhare, L. B., Goda, J. S., Gota, V., & Priyadarsini, K. I., Kunwar, A. (2021)
- 2020Prevention of acute graft-versus-host-disease by Withaferin a via suppression of AKT/mTOR pathway. International immunopharmacology, 84, 106575. https://doi.org/10.1016/j.intimp.2020.106575
Mehta, M., Gohil, D., Khattry, N., Kumar, R., Sandur, S., Sharma, D., Checker, R., Agarwal, B., Jha, D., Majumdar, A., & Gota, V.
Tuning the pharmacokinetics and efficacy of irinotecan (IRI) loaded gelatin nanoparticles through folate conjugation. International journal of pharmaceutics, 586, 119522. https://doi.org/10.1016/j.ijpharm.2020.119522Das, R. P., Chakravarti, S., Patel, S. S., Lakhamje, P., Gurjar, M., Gota, V., Singh, B. G., & Kunwar, A.
Objective assessment of intraoperative tumor fluorescence reveals biological heterogeneity within glioblastomas: a biometric study. Journal of neuro-oncology, 146(3), 477–488. https://doi.org/10.1007/s11060-019-03338-1Moiyadi, A., Shetty, P., Sridhar, E., Gota, V., Gurjar, M., Saicharan, G., Singh, V., & Srivastava, S.
Safety and pharmacokinetics of Withaferin-A in advanced stage high grade osteosarcoma: A phase I trial. Journal of Ayurveda and integrative medicine, 11(1), 68–72. https://doi.org/10.1016/j.jaim.2018.12.008Pires, N., Gota, V., Gulia, A., Hingorani, L., Agarwal, M., & Puri, A.
An HPLC method for simultaneous quantification of sunitinib and its active metabolite, SU12662, using hydrophilic interaction chromatography principle. Bioanalysis, 12(2), 75–85. https://doi.org/10.4155/bio-2019-0188Gurjar, M., Mehta, P., Sharma, J., Patil, S., Kulkarni, P., Patil, A., Nookala, M., Joshi, A., & Gota, V.
Xenogeneic transplantation of human WJ-MSCs rescues mice from acute radiation syndrome via Nrf-2-dependent regeneration of damaged tissues. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 20(8), 2044–2057. https://doi.org/10.1111/ajt.15819Bandekar, M., Maurya, D. K., Sharma, D., Checker, R., Gota, V., Mishra, N., & Sandur, S. K.
Randomized, Parallel Group, Open-Label Bioequivalence Trial of Intramuscular Pegaspargase in Patients With Relapsed Acute Lymphoblastic Leukemia. JCO global oncology, 6, 1009–1016. https://doi.org/10.1200/GO.20.00113Nookala Krishnamurthy, M., Narula, G., Gandhi, K., Awase, A., Pandit, R., Raut, S., Singh, R., Gota, V., & Banavali, S. D.
Response to: 500 mg as bolus followed by an extended infusion of 1500 mg of meropenem every 8 h failed to achieve in one-third of the patients an optimal PK/PD against nonresistant strains of these organisms: is CRRT responsible for this situation?. Annals of intensive care, 10(1), 164. https://doi.org/10.1186/s13613-020-00781-6Kothekar, A., Divatia, J. V., Myatra, S. N., & Gota, V.
Benzylidene thiazolidinediones: Synthesis, in vitro investigations of antiproliferative mechanisms and in vivo efficacy determination in combination with Imatinib. Bioorganic & medicinal chemistry letters, 30(23), 127561. https://doi.org/10.1016/j.bmcl.2020.127561Joshi, H., Patil, V., Tilekar, K., Upadhyay, N., Gota, V., & Ramaa, C. S.
Safety and CSF distribution of high-dose erlotinib and gefitinib in patients of non-small cell lung cancer (NSCLC) with brain metastases. European journal of clinical pharmacology, 76(10), 1427–1436. https://doi.org/10.1007/s00228-020-02926-9Shriyan, B., Patil, D., Gurjar, M., Nookala, M., Patil, A., Kannan, S., Patil, V., Joshi, A., Noronha, V., Prabhash, K., & Gota, V.
Double-blind trial of solid lipid Boswellia serrata particles (SLBSP) vs. standardized Boswellia serrata gum extract (BSE) for osteoarthritis of knee. Drug metabolism and personalized therapy, 35(2), /j/dmdi.2020.35.issue-2/dmpt-2020-0104/dmpt-2020-0104.xml. https://doi.org/10.1515/dmpt-2020-0104Kulkarni, P. D., Damle, N. D., Singh, S., Yadav, K. S., Ghante, M. R., Bhaskar, V. H., Hingorani, L., & Gota, V. S.
A comparison of asparaginase activity in generic formulations of E.coli derived L- asparaginase: In-vitro study and retrospective analysis of asparaginase monitoring in pediatric patients with leukemia. British journal of clinical pharmacology, 86(6), 1081–1088. https://doi.org/10.1111/bcp.14216Sankaran, H., Sengupta, S., Purohit, V., Kotagere, A., Moulik, N. R., Prasad, M., Dhamne, C., Narula, G., Banavali, S., & Gota, V.
A Limited Sampling Strategy for Therapeutic Drug Monitoring of Mycophenolate Mofetil for Prophylaxis of Acute Graft-Versus-Host Disease in Allogeneic Stem Cell Transplantation. Cell transplantation, 29, 963689720912925. https://doi.org/10.1177/0963689720912925Gota, V., Purohit, V., Gurjar, M., Nayak, L., Punatar, S., Gokarn, A., Bonda, A., Bagal, B., Vora, C. S., Patil, A., Nookala, M., & Khattry, N.
Clinical pharmacokinetics of 3-h extended infusion of meropenem in adult patients with severe sepsis and septic shock: implications for empirical therapy against Gram-negative bacteria. Annals of intensive care, 10(1), 4. https://doi.org/10.1186/s13613-019-0622-8Kothekar, A. T., Divatia, J. V., Myatra, S. N., Patil, A., Nookala Krishnamurthy, M., Maheshwarappa, H. M., Siddiqui, S. S., Gurjar, M., Biswas, S., & Gota, V.
- 2019Phase I/II Study of Palliative Triple Metronomic Chemotherapy in Platinum-Refractory/Early-Failure Oral Cancer. Journal of clinical oncology: official journal of the American Society of Clinical Oncology, 37(32), 3032–3041.
Patil, V. M., Noronha, V., Joshi, A., Dhumal, S., Mahimkar, M., Bhattacharjee, A., Gota, V., Pandey, M., Menon, N., Mahajan, A., Sable, N., Kumar, S., Nawale, K., Mukadam, S., Solanki, B., Das, S., Simha, V., Abraham, G., Chandrasekharan, A., Talreja, V., … Prabhash, K.
Population Pharmacokinetics of Pemetrexed in Adult Non-Small Cell Lung Cancer in Indian Patients. Journal of clinical pharmacology, 59(9), 1216–1224.Srinivasan, M., Chaturvedula, A., Fossler, M. J., Patil, A., Gota, V., & Prabhash, K.
Safety and pharmacokinetics of Withaferin-A in advanced stage high grade osteosarcoma: A phase I trial. J Ayurveda Integr Med, 11(1), 68-72. PMID: 30904387Pires, N., Gota, V., Gulia, A., Hingorani, L., Agarwal, M., & Puri, A. (2019)
Oral administration of 3,3'-diselenodipropionic acid prevents thoracic radiation induced pneumonitis in mice by suppressing NF-kB/IL-17/G-CSF/neutrophil axis. Free Radic Biol Med, 145, 8-19. PMID: 31521664Gandhi, K. A., Goda, J. S., Gandhi, V. V., Sadanpurwala, A., Jain, V. K., Joshi, K., Epari, S., Rane, S., Mohanty, B., Chaudhari, P., Kembhavi, S., Kunwar, A., Gota, V., & Priyadarsini, K. I. (2019)
Phase I/II Study of Palliative Triple Metronomic Chemotherapy in Platinum-Refractory/Early-Failure Oral Cancer. J Clin Oncol, 37(32), 3032-3041. PMID: 31539316Patil, V. M., Noronha, V., Joshi, A., Dhumal, S., Mahimkar, M., Bhattacharjee, A., Gota, V., Pandey, M., Menon, N., Mahajan, A., Sable, N., Kumar, S., Nawale, K., Mukadam, S., Solanki, B., Das, S., Simha, V., Abraham, G., Chandrasekharan, A., Talreja, V., DSouza, H., Srinivas, S., Kashyap, L., & Banavali, S. (2019)