Cancer chemotherapy is often associated with the adverse events and many times this leads to interruption of the therapy or even discontinuation of the cancer chemotherapy. New approaches to improve tolerability and reduce adverse sequelae of cancer chemotherapy are urgently needed. One such approach is the combination of natural bioactive compounds with traditional chemotherapeutic drugs which can potentiate anti-cancer efficacy and reduce side-effects of chemotherapy. Docetaxel-based chemotherapy is commonly used for many solid cancers. The common side effects of Docetaxel are low white blood cell count and low red blood cell count, occurring in greater than 30% for patients taking Docetaxel. Based on the traditional literature of Guduchi (Tinospora cordifolia), its clinical usage experience, experimental studies related evidences and biological plausibility derivable from plant-attributes; Guduchi has the potential to countercheck the adverse events of cancer chemotherapy and complement in the overall cancer management. Most promising effects of Tinospora cordifolia demonstrated is immunomodulatory activity through increase in GM-CSF which leads to leukocytosis and improved neutrophil function. This study will help to determine whether the addition of a standardized water extract of Tinospora cordifolia, to docetaxel-based chemotherapy, will help reduce the adverse effects and improve Quality of Life (QoL). The study will be done in advanced/metastatic solid tumor commonly treated with Docetaxel based chemotherapy.