Epigenetic changes like histone post translational modifications and change in chromatin architecture are key events that regulate gene expression. The N-terminal tail of histones can be modified by acetylation, phosphorylation, methylation, sumoylation, ubiquitination etc. This is an orchestrated event of “Writers” (that add modifications), “Readers” (that recognize the modification) and “Erasers” (that remove the modifications). This create an epigenetic mechanism for the regulation of a variety of normal and disease related processes by influencing and regulating gene transcription. Few of these modifications have been strongly linked to cancer and referred to as “histone onco modifications”. Further these histone PTMs are known to regulate the modification at neighbouring as well as distant sites of histones. A combination of these modifications forms a code, a language which results in diverse cellular processes.