Professor
Our interdisciplinary team integrates cutting-edge research methodologies involving pharmacology, toxicology, and mechanistic investigations, thereby driving advancements in drug development, personalized medicine, and therapeutic interventions. From our preclinical research endeavors to our specialized bioanalytical division and a state-of-the-art Phase 1 unit, we're dedicated to pioneering bedside-to-bench onco-pharmacology for a healthier tomorrow.
Clinical Research: The department has an active phase-1 unit to support pharmacokinetic, pharmacogenetic, BA/BE and first-in-human clinical trials. The 4- bed ward is a specialized unit capable of providing round the clock care and supervision to the study participants under the stewardship of an excellent team of study investigators, medical oncology and nursing staff.
Pre-Clinical Research: The department is actively involved in developing therapeutic interventions for various cancers as well as the mitigation of serious adverse effects associated with cancer treatment. This includes development of radioprotectors and drugs for the prevention of morbidities associated with bone marrow transplantation such as graft versus host disease (GvHD). The pharmacokinetics and efficacy of drugs in special situations such as malnutrition are also being investigated. Efficacy of mitochondria-targeted drugs in therapy-resistant cancers is also being investigated. The lab undertakes end-to-end non-clinical investigations including pharmacokinetics and biodistribution, toxicity, efficacy and mechanistic studies.
Cancer chemotherapy is often associated with the adverse events and many times this leads to interruption of the… more
MSP008-22 is a novel molecule with anticancer effects demonstrated in in-vitro and in-vivo animal studies. Speci… more
Sunitinib is an oral multi-targeted tyrosine kinase inhibitor approved for the first-line treatment of metastati… more
Adverse event (AE) reporting is crucial in oncology for evaluating the safety and efficacy of treatments. Common… more
Over 55% of all malignancies occur in persons aged 65 years or older. Ageing brings about various physiological… more
While usage of tobacco in any form is associated with higher risk of developing oral cancer, difference in the a… more
Radiation Therapy (RT) either alone or in combination with chemotherapy (chemoradiotherapy-CTRT) is one of the c… more
Mucositis is a consequence of high dose chemotherapy that is administered to patients undergoing bone marrow tra… more
This proposed study seeks to investigate the effect of malnutrition on the pharmacokinetics of chemotherapy drug… more
The effective management of critically ill patients in Intensive Care Units (ICUs) heavily relies on the precise… more
Adverse events (AEs) can significantly impact patient health. The implicating drugs have to either stopped or de… more
The kidneys play a very important role in xenobiotic elimination. Renal function is known to decrease with advan… more
In the present study, we propose to study inter-individual variability in breast cancer outcomes, toxicity and… more
Dasatinib is an orally active, tyrosine kinase inhibitor that has demonstrated manageable safety and high respon… more
I am the active member of the EORTC Quality of Life questionnaire Group (EORTC QLG) and involved in conducting m… more
While usage of tobacco in any form is associated with higher risk of developing oral cancer, difference in the a… more
Malnutrition is a significant problem in paediatric oncology, and carries poor prognosis due to higher toxicity… more
NSCLC is any type of epithelial lung cancer other than Small Cell Lung Cancer (SCLC), it constitutes 85% of all… more
Radiation therapy and chemotherapy are potent tools against cancer, yet they often result in unintended harm to… more
Ayurvedic medicinal plants have been traditionally used for their therapeutic properties, and modern scientific… more
Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumour. Challenges associated with therapeu… more
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and contributes 85% of all lung cancer… more
Approximately 40% children with cancer are malnourished at diagnosis. Malnutrition in young children with cancer… more
Hematopoietic Stem Cell Transplantation (HSCT) is a procedure of infusing healthy blood forming stem cells into… more
Scientific Officer 'F'
Scientific Officer 'F'
Scientific Officer 'D'
Scientific Officer 'D'
Kumar, S., Castelino, R., Rao, A., Gattani, S., Kumar, A., Pillai, A., Sehgal, A., Rane, P., Ramaswamy, A., Dhekale, R., Krishnamurthy, J., Banavali, S., Badwe, R., Prabhash, K., Noronha, V., & Gota, V. (2024)
Gupta, S. K., Gohil, D., Momin, M. B., Yadav, S., Chichra, A., Punatar, S., Gokarn, A., Mirgh, S., Jindal, N., Nayak, L., Hingorani, L., Khattry, N., & Gota, V. (2024)
Batcha, J. S. D., Gota, V., Matcha, S., Raju, A. P., Rao, M., Udupa, K. S., & Mallayasamy, S. (2024)
Gaur, T., Ali, A., Sharma, D., Gupta, S. K., Gota, V., Bagal, B., Platzbeckar, U., Mishra, R., Dutt, A., Khattry, N., Mills, K., Hasan, M. I., Sandur, S., & Hasan, S. K. (2024)