In the present study, we propose to study inter-individual variability in breast cancer outcomes, toxicity and quality of life by integrating Ayurvedic principles with modern methods of investigation. The study will enable us to understand the significance of Prakriti in prognosticating safety and efficacy of cancer treatment. This will further enable us to customise the dose of anti-cancer drug based on individual susceptibilites as per Prakriti. Since adverse events are the major cause of morbidity, mortality and out of pocket expenditure in cancer, predicting these events will result in better overall outcomes and avoid financial toxicities to patients. And if microbiome is invovled in the process of Prakriti influence on breast cancer outcomes, intevention related to restoration of dysbiosis can be adopted in cancer care.