is a flagship study funded by the Department of Biotechnology, Government of India. This is a multi-institutional study between The Tata Memorial Centre (TMH & ACTREC), The National Institute of Biomedical Genomics (NIBMG), Kalyani and National Centre for Cell Sciences (NCCS), Pune. The VNCI study aims using a variety of multi-omics big data technologies comprehensive characterization of endocrine hormone therapy resistant and sensitive breast cancer tumours, in hormone receptor positive, HER2 -ve breast cancer patients. The integration of data from these OMICs assays with observed clinical phenotypes and drug responses will help derive a holistic understanding of mechanisms of resistance and sensitivity to endocrine hormone therapy.